u2 snrnp การใช้

• Splicing factor 3b associates with both the U2 and U11 / U12 small nuclear ribonucleoprotein complexes ( U2 snRNP ) of spliceosomes.
• Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex ( U2 snRNP ).
• The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing.
• It is a mixture of modifications involving that of the pseudouridine residues that assist in the complete assembly of the 17S U2 snRNP particle needed for splicing.
• The association of U6 snRNP with U2 snRNP via base-pairing forms the U6-U2 complex, a structure that comprises the active site of the spliceosome.
• SR proteins combine with SR-like proteins to select exon splicing enhancers on RNA transcripts causing U2 snRNP to bind to the upstream, adjacent branch site causing spliceosome assembly at the specific 3'site selected by the SR proteins.
• The splicing factor 3b / 3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA . Splicing factor 3b is also a component of the minor U12-type spliceosome.
• The splicing factor 3b / 3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA . Splicing factor 3b is also a component of the minor U12-type spliceosome.